Diabetes mellitus is a metabolic disease in which chronic hyperglycemia develops. Diabetes mellitus is of 2 types - insulin-dependent and insulin-independent.
Genetic predisposition, unbalanced diet, obesity, or concomitant pathologies can lead to the development of the disease. In the treatment of non-insulin dependent diabetes mellitus, specialized drugs are used that have a pronounced hypoglycemic effect.
One of the best drugs of this type are tablets Mephogamma. The active ingredient of the drug is metformin. The drug is available in various dosages. The most common are 850 and 1000 mg. Even in pharmacies for sale Metfohama 500.
Price and principle of action of the drug
How much does the medicine cost? The price depends on the amount of metformin in the preparation. At Mettogamma 1000 the price is 580-640 rubles. Mettopogamma 500 mg costs about 380-450 rubles. At Mettogamm 850, the price starts from 500 rubles. It is worth noting that the drugs are available only by prescription.
Make medicine in Germany. The official representative office is located in Moscow. In the 2000s, the manufacture of the drug was established in the city of Sofia (Bulgaria).
What is the principle of the action of the medicine? Metformin (the active ingredient of the drug) reduces the concentration of glucose in the blood. This is achieved by inhibiting gluconeogenesis in the liver. Metformin also improves glucose utilization in the tissues and reduces the absorbability of sugar from the digestive tract.
It is noteworthy that when using the drug, the level of cholesterol and LDL in the serum is reduced. But Metformin does not change the concentration of lipoproteins. When using the medication you can lose weight. Usually, Metogram 500, 850 and 100 mg is used when diet does not help to reduce body weight.
Metformin not only reduces blood sugar, but also significantly improves blood fibrinolytic properties.
This is achieved by suppressing a tissue-type plasminogen inhibitor.
Instructions for use of the drug
When is the use of the drug Metfohamma 500 justified? The instructions for use say that the drug should be used in the treatment of non-insulin-dependent diabetes mellitus type 2. But Metfohamma 1000, 500 and 800 mg should be used in the treatment of patients who are not prone to ketoacidosis.
How to take medicine? The dosage is selected based on the level of glucose in the blood. Usually the initial dose is 500-850 mg. If the medicine is used to maintain normal sugar levels, the daily dose may be increased to 850-1700 mg.
It is necessary to use the medicine in 2 doses. How long should I take the medicine? For the drug Metfohamma 850, the instruction does not regulate the duration of therapy. The duration of treatment is chosen individually and depends on many factors.
In Metfohama 1000, the instructions for use regulate such contraindications for use:
- Diabetic ketoacidosis.
- Abnormalities in the kidneys.
- Heart failure.
- Violation of cerebral circulation.
- Chronic alcoholism.
- Acute myocardial infarction phase.
- Liver dysfunction.
- Alcohol poisoning.
- Lactic acidosis
- Lactation period.
- Allergy to metformin and auxiliary components of the drug.
Reviews of physicians suggest that the drug should not be consumed during the period of observance of a low-calorie diet, which provides for consumption of less than 1000 calories per day. Otherwise, the pharmaceutical drug Metfohama 1000 can cause serious complications, even diabetic coma.
The drug is usually well tolerated by patients. But with long-term medication can not exclude the likelihood of such side effects as:
- Megaloblastic anemia.
- Disorders in the work of the digestive tract. Metphogamma 1000 can cause dyspeptic symptoms, nausea, vomiting and diarrhea. Also, during treatment therapy, a metallic taste may appear in the mouth.
- Lactic acidosis.
- Allergic reactions.
The development of lactic acidosis suggests that it is better to interrupt the course of treatment.
If this complication occurs, you should immediately undergo symptomatic therapy.
Drug interactions and drug analogues
How does Metphogamma 1000 interact with other drugs? The instructions say that the drug can reduce the effectiveness of treatment with the use of anticoagulants.
It is not recommended to use the medicine for diabetes along with MAO inhibitors, ACE inhibitors, clofibrate derivatives, cyclophosphamides or beta-blockers. The interaction of metformin with the above drugs increases the risk of increased hypoglycemic action.
What are the most effective analogues of the drug Metfohamma 1000? According to doctors, the best alternative are:
- Glucophage (220-400 rubles). This drug is as good as Metphogamma. The active ingredient of the drug is metformin. The drug helps to reduce blood sugar levels and increase the sensitivity of peripheral insulin receptors.
- Glibomet (320-480 rubles). The drug inhibits lipolysis in adipose tissue, stimulates the peripheral sensitivity of tissues to the action of insulin and reduces blood sugar levels.
- Siofor (380-500 rubles). The drug inhibits the absorption of glucose in the intestine, improves the utilization of sugar in muscle tissue and reduces the production of glucose in the liver.
The above medications are recommended for use with non-insulin-dependent diabetes mellitus type 2. When choosing an analogue, you should consult with your doctor, as drugs to reduce glucose can cause lactic acidosis. The video in this article continues the theme of using Metformin in diabetes.