At elevated pressure, lisinopril and indapamide are used in combination. The drugs are well compatible, and the effect while taking it is much higher. Within 24 hours, pressure is reduced, and the work of the heart muscle is improved. The excretion of fluid from the body is enhanced, the blood vessels are dilated, and the general condition of the body is improved in patients with arterial hypertension. Combined treatment helps reduce the risk of complications of the cardiovascular system.
Characteristics of Lisinopril
The drug belongs to the group of ACE inhibitors. The active ingredient is lisinopril dihydrate in the amount of 5.4 mg, 10.9 mg, or 21.8 mg. The drug prevents the formation of angiotensin octapeptide, which contributes to increased pressure. After taking the vessels dilate, blood pressure decreases, the load on the heart muscle decreases.
At elevated pressure, lisinopril and indapamide are used in combination.
In heart failure, the body adapts more quickly to physical exertion. The tool has an antihypertensive effect, prevents a painful increase in the myocardium and reduces the risk of severe consequences for the vessels and the heart. Absorbed quickly and completely from the digestive tract. Act means begins after 1 hour. Within 24 hours, the effect increases, and the patient's condition returns to normal.
How does indapamide
This tool refers to diuretics. The composition contains the active substance of the same name in the amount of 1.5 or 2.5 mg. The drug removes from the body sodium, calcium, chlorine and magnesium. After application, diuresis becomes more frequent, and the vascular wall becomes less sensitive to the action of angiotensin 2, therefore pressure decreases.
The drug prevents the formation of free radicals in the body, reduces the fluid content in the tissues, dilates blood vessels. Does not affect the concentration of cholesterol, glucose or triglycerides in the blood. From the digestive tract absorbed by 25%. After a single dose, the pressure stabilizes during the day. The condition improves within 2 weeks of regular use.
The combined effect of Lisinopril and Indapamide
Both drugs promote rapid and effective pressure reduction. Under the action of indapamide there is a loss of fluid, and the vessels relax. Lisinopril dihydrate also contributes to the relaxation of blood vessels and prevents re-pressure increase. Comprehensive treatment has a more pronounced hypotensive effect.
Lisinopril and Indapamide promote rapid and effective pressure reduction.
Indications for simultaneous use
Joint reception is shown at long increase in arterial pressure. Indapamide also eliminates edema in chronic heart failure.
Contraindications to Lizinopril and Indapamid
It is not always allowed to take these funds at the same time. The combination of drugs is contraindicated in certain diseases and conditions:
- elderly age;
- allergic to components of drugs;
- the presence of angioedema in history;
- kidney failure;
- creatinine level less than 30 mmol / l;
- low content of potassium in the blood plasma;
- inability to digest lactose;
- impaired conversion of galactose into glucose;
- breastfeeding period;
- children up to 18 years;
- arterial hypertension.
It is prohibited to simultaneously take funds containing Aliskiren. Caution should be exercised with elevated levels of uric acid in the blood, coronary heart disease, dehydration, chronic heart and kidney failure. Patients with bilateral renal artery stenosis, elevated potassium levels, and cerebral circulatory insufficiency should limit the intake. It is impossible to begin treatment in conjunction with the operation, the use of anesthetics, potassium preparations and high-flow dialysis membrane.
How to take Lisinopril and Indapamide
Reception is carried out regardless of the use of food. The dosage of drugs depends on the patient's condition and the response to combination therapy.
Before starting treatment, you need to consult a doctor and be examined.
The recommended daily dosage at elevated pressure is 1.5 mg of indapamide and 5.4 mg of lisinopril dihydrate. With good tolerance, the dosage can be gradually increased. The duration of treatment is at least 2 weeks. The effect occurs within 2-4 weeks of treatment.
In the morning or evening
Tablets are best taken in the morning once.
During the reception, some adverse reactions may occur:
- dryness of the oral mucosa;
- labored breathing;
- increased liver enzymes;
- increased blood glucose levels;
- decrease in the concentration of chlorides in the blood;
- impaired renal function and liver.
If the above symptoms appear, you must stop taking it.
Opinion of doctors
Elena Igorevna, cardiologist
The successful combination of diuretic and ACE inhibitor. Much safer and more efficient than analogs. Pressure decreases within 2-4 weeks.
Valentin Petrovich, cardiologist
Minimal risk of side effects. But in childhood the combination is not prescribed, and elderly patients and people with impaired liver or kidney function may require dose adjustment.
Elena, 42 years old
In hypertension, she began taking 2 drugs with an increased dosage — 10 mg of lisinopril and 2.5 mg of indapamide. I took the pills in the morning and I felt good until the evening. Then the pressure rose sharply to 140/95 mm. Hg I had to reduce the dosage. Also in the instructions written about the side effects of coughing and nausea. Symptoms appear with prolonged use.
Roman, 37 years old
I take 2 drugs for pressure. There are no side effects. Sometimes dizziness is felt, so you need to drive carefully.